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News Archives 2021-2040
Number Title Post Date
2021 TV Editor Kills Himself On Champix Drug Sanctioned by NICE 18/04/2008 15:47:08
2022 65% Of Autistic Children Have Mitochondrial Dysfunction 18/04/2008 15:52:17
2023 ME/CFS Protest - Royal Society of Medicine Conference 20/04/2008 07:26:59
2024 Infections in Neurodegenerative and Neurobehavioral Disease 20/04/2008 07:33:03
2025 ME/CFS As A Mitochondrial Disease 20/04/2008 07:36:36
2026 Medical Research To Tackle Mitochondrial Toxicity of Drugs 20/04/2008 07:40:25
2027 Scottish Schools "Sick" Says Education Design Tsar 20/04/2008 07:45:13
2028 Dishonest Vitamin Analysis Study A Con 20/04/2008 07:47:42
2029 Study Confirms Parkinsons-Pesticides Link 20/04/2008 07:54:13
2030 Medical Journal Articles Written By Ghosts 20/04/2008 08:18:16
2031 FDA Relies On Fraudulent Industry Studies To Judge Safety 20/04/2008 08:20:24
2032 Something In The Air - BBC1 Panorama On Monday 20/04/2008 08:30:03
2033 ADHD Children With Heart Conditions Die On Ritalin 22/04/2008 09:35:06
2034 FDA Slammed On Drug Manufacturer Inspections 23/04/2008 10:30:47
2035 Psychiatrists Dispute Heart Testing Ritalin Kids 23/04/2008 10:32:30
2036 All Presidential Candidates Support Vaccines/Autism Link 23/04/2008 10:42:07
2037 Toxic Anthrax Vaccine Forced On Military Recruits 24/04/2008 10:17:36
2038 Baby Dies After MMR Jab - Verdict "Natural Causes" 24/04/2008 10:41:39
2039 More Babies Dead After Measles Vaccination 24/04/2008 10:45:35
2040 Toxic Aircraft Fumes - Full Investigation Required 25/04/2008 10:03:56

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65% Of Autistic Children Have Mitochondrial Dysfunction
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Schafer Autism Report
RESEARCH
65% Autistic Children Found To Have Mitochondrial Disorder


At an American Academy of Neurology meeting last Sunday it was revealed in a recent research paper, see below, that 65% of children with Autistic Spectrum Disorders assessed were found to have mitochondrial disorder (MtD) and so were always at risk of autism caused by one or more vaccines.

Oxidative Phosphorylation (OXPHOS) Defects in Children with Autistic Spectrum Disorders [IN1-1.004]

John Shoffner, Lauren C. Hyams, Genevieve N. Langley, Atlanta, GA

OBJECTIVE: To retrospectively survey patients with autistic spectrum disorders that were evaluated clinically for mitochondrial disease and to assess the clinical and laboratory features of this group of patients.

BACKGROUND: Autism is a developmental disorder characterized by disturbance in language, perception and socialization. A variety of biochemical, anatomical and neuroradiographical studies imply a disturbance of brain energy metabolism in autistic patients. Recent studies confirmed the previously reported high frequency of biochemical markers of mitochondrial dysfunction, namely hyperlactacidemia and increased lactate/pyruvate ratio, in a significant fraction of 210 autistic patients. (J Autism Dev Disord, 2006. 36:1137) Although rare, Mecp2 mutations can produce autistic features and the mouse model has significant mitochondrial defects. (Mol Cell Biol, 2006. 26: 5033) Additional genetic defects associated with mitochondrial dysfunction include inverted 15q11-13 duplication (Complex III defect) (Ann Neurol, 2003,53,801), A3243G mutation (mitochondrial transfer RNALeucine(UUR) gene, mtDNA depletion(J Pediatr, 2004,144,81), G8363A mutation (mitochondrial transfer RNALysine gene. (J Child Neurol, 2000,15,357).

DESIGN/METHODS: Retrospective analysis of 37 children with autistic spectrum disorders. Clinical, biochemical, metabolic, and genetic data is assessed.

RESULTS: Twenty four children (65%) had skeletal muscle OXPHOS defects: Complex I (16), Complex I and Complex III (5), Complex III (1), Complex I and Complex IV (2). Thirteen (35%) had normal skeletal muscle OXPHOS enzyme activities for Complexes I-IV. Clinical, metabolic, protein chemistry, and sequencing of coding regions of the mitochondrial DNA will be reported.

CONCLUSIONS/RELEVANCE: Most children with autistic spectrum disorders do not have recognizable abnormalities on a broad range of imaging, metabolic and genetic studies. However, a subset of patients do harbor significant defects in oxidative phosphorylation function. Complex I abnormalities are the most frequently encountered defect. Recognition of these children is important for understanding how genes that produce autistic spectrum disorders impact mitochondrial function. Supported by: Horizon Molecular Medicine.

Category - Neurogenetics and Gene Therapy
SubCategory - Other
Sunday, April 13, 2008 2:45 PM
Platform Session: Integrated Neuroscience: Autism (2:00 PM-3:15 PM) Annual Meeting American Academy of Neurology

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For Further Information:
* Hannah Poling Autism-Vaccine Case:
Implications for ME/CFS-labelled patients

* Seismic Vaccines Shift On Autism Debate


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